| Reaction Details |
|---|
 | Report a problem with these data |
| Target | L-lactate dehydrogenase B chain |
|---|
| Ligand | BDBM50441132 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_984203 (CHEMBL2432256) |
|---|
| IC50 | 12000±n/a nM |
|---|
| Citation |  Fauber, BP; Dragovich, PS; Chen, J; Corson, LB; Ding, CZ; Eigenbrot, C; Giannetti, AM; Hunsaker, T; Labadie, S; Liu, Y; Liu, Y; Malek, S; Peterson, D; Pitts, K; Sideris, S; Ultsch, M; VanderPorten, E; Wang, J; Wei, B; Yen, I; Yue, Q Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett23:5533-9 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| L-lactate dehydrogenase B chain |
|---|
| Name: | L-lactate dehydrogenase B chain |
|---|
| Synonyms: | L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46 |
|---|
| Type: | Oxidoreductase; homotetramer |
|---|
| Mol. Mass.: | 36635.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 334 |
|---|
| Sequence: | MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
|
|
|
|---|
| BDBM50441132 |
|---|
| n/a |
|---|
| Name | BDBM50441132 |
|---|
| Synonyms: | CHEMBL2430737 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18N4O2 |
|---|
| Mol. Mass. | 334.3718 |
|---|
| SMILES | C[C@@H](Nc1nc(cnc1N)-c1cccc(c1)C(O)=O)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
