| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 2 |
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| Ligand | BDBM50441979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_992590 (CHEMBL2447183) |
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| IC50 | 49100±n/a nM |
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| Citation |  Zheng, YC; Duan, YC; Ma, JL; Xu, RM; Zi, X; Lv, WL; Wang, MM; Ye, XW; Zhu, S; Mobley, D; Zhu, YY; Wang, JW; Li, JF; Wang, ZR; Zhao, W; Liu, HM Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration. J Med Chem56:8543-60 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 2 |
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| Name: | Lysine-specific histone demethylase 2 |
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| Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92112.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_992590 |
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| Residue: | 822 |
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| Sequence: | MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
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| BDBM50441979 |
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| n/a |
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| Name | BDBM50441979 |
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| Synonyms: | CHEMBL2334497 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26FN5O2S2 |
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| Mol. Mass. | 451.581 |
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| SMILES | CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCc1cn(Cc2ccccc2F)nn1 |
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| Structure | 
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