Reaction Details |
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Target | Lysine-specific histone demethylase 1A |
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Ligand | BDBM50442016 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_992728 (CHEMBL2443630) |
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IC50 | 81300±n/a nM |
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Citation | Zheng, YC; Duan, YC; Ma, JL; Xu, RM; Zi, X; Lv, WL; Wang, MM; Ye, XW; Zhu, S; Mobley, D; Zhu, YY; Wang, JW; Li, JF; Wang, ZR; Zhao, W; Liu, HM Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration. J Med Chem56:8543-60 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific histone demethylase 1A |
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Name: | Lysine-specific histone demethylase 1A |
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
Type: | Enzyme |
Mol. Mass.: | 92901.01 |
Organism: | Homo sapiens (Human) |
Description: | O60341 |
Residue: | 852 |
Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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BDBM50442016 |
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n/a |
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Name | BDBM50442016 |
Synonyms: | CHEMBL2440541 |
Type | Small organic molecule |
Emp. Form. | C20H27N5O4S2 |
Mol. Mass. | 465.589 |
SMILES | CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCc1cn(Cc2ccc(O)cc2O)nn1 |
Structure |
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