| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM50442673 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_989151 (CHEMBL2446214) |
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| IC50 | 1.8±n/a nM |
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| Citation |  Dwyer, MP; Keertikar, K; Paruch, K; Alvarez, C; Labroli, M; Poker, C; Fischmann, TO; Mayer-Ezell, R; Bond, R; Wang, Y; Azevedo, R; Guzi, TJ Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach. Bioorg Med Chem Lett23:6178-82 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM50442673 |
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| n/a |
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| Name | BDBM50442673 |
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| Synonyms: | CHEMBL2442291 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N7O |
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| Mol. Mass. | 335.3632 |
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| SMILES | Cc1nnc(o1)-c1cccc(c1)-c1cnn2ccc(NCCN)nc12 |
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| Structure | 
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