Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-2 | ||
Ligand | BDBM50442693 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_989149 (CHEMBL2446212) | ||
IC50 | 190±n/a nM | ||
Citation | Dwyer, MP; Keertikar, K; Paruch, K; Alvarez, C; Labroli, M; Poker, C; Fischmann, TO; Mayer-Ezell, R; Bond, R; Wang, Y; Azevedo, R; Guzi, TJ Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach. Bioorg Med Chem Lett23:6178-82 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-2 | |||
Name: | Serine/threonine-protein kinase pim-2 | ||
Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 34185.93 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9P1W9 | ||
Residue: | 311 | ||
Sequence: |
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BDBM50442693 | |||
n/a | |||
Name | BDBM50442693 | ||
Synonyms: | CHEMBL2442316 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23N5 | ||
Mol. Mass. | 357.4515 | ||
SMILES | N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3ccc4ccccc4c3)c2n1 |r,wU:1.0,wD:4.7,(62.54,-18.45,;63.88,-17.68,;63.89,-16.14,;65.21,-15.38,;66.54,-16.16,;66.55,-17.69,;65.21,-18.46,;67.88,-15.39,;69.21,-16.16,;69.21,-17.7,;70.54,-18.47,;71.87,-17.7,;73.35,-18.18,;74.26,-16.93,;73.35,-15.67,;73.83,-14.21,;72.8,-13.07,;73.27,-11.61,;74.78,-11.28,;75.24,-9.82,;76.76,-9.51,;77.8,-10.65,;77.32,-12.12,;75.81,-12.43,;75.34,-13.89,;71.87,-16.15,;70.54,-15.39,)| | ||
Structure |