| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
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| Ligand | BDBM50443351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1275524 (CHEMBL3090539) |
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| IC50 | 0.740000±n/a nM |
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| Citation |  Debenham, JS; Graham, TH; Verras, A; Zhang, Y; Clements, MJ; Kuethe, JT; Madsen-Duggan, C; Liu, W; Bhatt, UR; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Li, X; Lisnock, J; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xu, S; Hale, JJ; Pinto, S; Shen, DM Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett23:6228-33 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal Pro-X carboxypeptidase |
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| Name: | Lysosomal Pro-X carboxypeptidase |
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| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55028.96 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1335505 |
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| Residue: | 491 |
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| Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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| BDBM50443351 |
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| n/a |
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| Name | BDBM50443351 |
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| Synonyms: | CHEMBL3086037 | US8669252, 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31BrClN3O2 |
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| Mol. Mass. | 568.932 |
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| SMILES | Clc1ccc(cc1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccncc1 |r| |
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| Structure | 
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