Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50443877 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1277839 (CHEMBL3097773) |
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IC50 | 32400±n/a nM |
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Citation | Fukunaga, K; Uehara, F; Aritomo, K; Shoda, A; Hiki, S; Okuyama, M; Usui, Y; Watanabe, K; Yamakoshi, K; Kohara, T; Hanano, T; Tanaka, H; Tsuchiya, S; Sunada, S; Saito, K; Eguchi, J; Yuki, S; Asano, S; Tanaka, S; Mori, A; Yamagami, K; Baba, H; Horikawa, T; Fujimura, M 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3ß inhibitors. Bioorg Med Chem Lett23:6933-7 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50443877 |
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n/a |
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Name | BDBM50443877 |
Synonyms: | CHEMBL3091539 |
Type | Small organic molecule |
Emp. Form. | C19H18FN5O2 |
Mol. Mass. | 367.3769 |
SMILES | Cn1c(nc(cc1=O)-c1ccncn1)N1CCO[C@H](C1)c1ccccc1F |r| |
Structure |
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