Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50444409 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1279808 (CHEMBL3095509) |
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EC50 | 174000±n/a nM |
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Citation | Stevens, BD; Litchfield, J; Pfefferkorn, JA; Atkinson, K; Perreault, C; Amor, P; Bahnck, K; Berliner, MA; Calloway, J; Carlo, A; Derksen, DR; Filipski, KJ; Gumkowski, M; Jassal, C; MacDougall, M; Murphy, B; Nkansah, P; Pettersen, J; Rotter, C; Zhang, Y Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. Bioorg Med Chem Lett23:6588-92 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | Gck | HXK4_RAT | Hexokinase type IV |
Type: | PROTEIN |
Mol. Mass.: | 52101.81 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1279785 |
Residue: | 465 |
Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
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BDBM50444409 |
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n/a |
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Name | BDBM50444409 |
Synonyms: | CHEMBL3091581 |
Type | Small organic molecule |
Emp. Form. | C21H26N4O5S |
Mol. Mass. | 446.52 |
SMILES | OC(=O)c1ccc(NC(=O)[C@H](CC2CCCC2)n2cnc(c2)S(=O)(=O)C2CCC2)nc1 |r| |
Structure |
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