| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinic acetylcholine receptor alpha9/alpha10 |
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| Ligand | BDBM50445331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1285311 (CHEMBL3107561) |
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| IC50 | >10000±n/a nM |
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| Citation |  Luo, S; Zhangsun, D; Zhu, X; Wu, Y; Hu, Y; Christensen, S; Harvey, PJ; Akcan, M; Craik, DJ; McIntosh, JM Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors. J Med Chem56:9655-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinic acetylcholine receptor alpha9/alpha10 |
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| Name: | Nicotinic acetylcholine receptor alpha9/alpha10 |
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| Synonyms: | Neuronal acetylcholine receptor subunit alpha-10/alpha-9 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2193071 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit alpha-9 |
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| Synonyms: | ACHA9_RAT | Acra9 | Cholinergic, Nicotinic Muscle | Chrna9 | NACHR alpha 9 | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha 9 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54522.69 |
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| Organism: | RAT |
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| Description: | Cholinergic, Nicotinic Muscle 0 RAT::P43144 |
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| Residue: | 479 |
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| Sequence: | MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTL
QVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLY
NKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNG
NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLS
PRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCAR
YEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD
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| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit alpha-10 |
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| Synonyms: | ACH10_RAT | Chrna10 | Neuronal acetylcholine receptor protein alpha-10 subunit | Nicotinic acetylcholine receptor alpha9/alpha10 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49830.54 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_143222 |
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| Residue: | 447 |
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| Sequence: | MGTRSHYLDLGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLE
VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYN
KADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGH
QLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
CNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGK
YYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCVRERGEPCGQS
KPLESAPSLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRAAQRRHEDWKRLA
RVMDRFFLGIFFCMALVMSLIVLVQAL
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| BDBM50445331 |
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| n/a |
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| Name | BDBM50445331 |
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| Synonyms: | CHEMBL3104245 |
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| Type | Small organic molecule |
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| Emp. Form. | C58H92N18O18S5 |
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| Mol. Mass. | 1489.786 |
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| SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@H](NC(=O)CN)C(=O)N[C@@H](CSSC[C@H](NC1=O)C(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N2 |r| |
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| Structure | 
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