| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-Dependent Kinase 2 (CDK2) |
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| Ligand | BDBM50446436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1287774 |
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| IC50 | 230±n/a nM |
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| Citation |  Naud S; Westwood IM; Faisal A; Sheldrake P; Bavetsias V; Atrash B; Cheung KM; Liu M; Hayes A; Schmitt J; Wood A; Choi V; Boxall K; Mak G; Gurden M; Valenti M; de Haven Brandon A; Henley A; Baker R; McAndrew C; Matijssen B; Burke R; Hoelder S; Eccles SA; Raynaud FI; Linardopoulos S; van Montfort RL; Blagg J Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem 56:10045-65 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-Dependent Kinase 2 (CDK2) |
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| Name: | Cyclin-Dependent Kinase 2 (CDK2) |
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| Synonyms: | CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2A) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| Component 2 |
| Name: | Cyclin-A2 |
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| Synonyms: | CCN1 | CCNA | CCNA1 | Cyclin A | Cyclin-A |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 48550.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 432 |
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| Sequence: | MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRG
LAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKI
EREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHE
DIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYID
RFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK
VLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAF
HLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHG
VSLLNPPETLNL
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| BDBM50446436 |
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| n/a |
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| Name | BDBM50446436 |
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| Synonyms: | CHEMBL3109952 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N6O2 |
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| Mol. Mass. | 404.465 |
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| SMILES | C(CN1CCOCC1)Oc1ccc(Nc2cc3[nH]c(cc3cn2)-c2cn[nH]c2)cc1 |
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| Structure | 
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