Reaction Details |
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Target | Intestinal-type alkaline phosphatase |
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Ligand | BDBM50447413 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1288273 (CHEMBL3117347) |
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IC50 | 3800±n/a nM |
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Citation | Ardecky, RJ; Bobkova, EV; Kiffer-Moreira, T; Brown, B; Ganji, S; Zou, J; Pass, I; Narisawa, S; Iano, FG; Rosenstein, C; Cheltsov, A; Rascon, J; Hedrick, M; Gasior, C; Forster, A; Shi, S; Dahl, R; Vasile, S; Su, Y; Sergienko, E; Chung, TD; Kaunitz, J; Hoylaerts, MF; Pinkerton, AB; Millán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett24:1000-4 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Intestinal-type alkaline phosphatase |
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Name: | Intestinal-type alkaline phosphatase |
Synonyms: | Akp-3 | Akp3 | Iap | Intestinal alkaline phosphatase | PPBI_MOUSE |
Type: | PROTEIN |
Mol. Mass.: | 60286.13 |
Organism: | Mus musculus |
Description: | ChEMBL_1288277 |
Residue: | 559 |
Sequence: | MQGPWVLLLLGLRLQLSLSVIPVEEENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLG
DGMGVPTVTATRILKGQLEGHLGPETPLAMDRFPYMALSKTYSVDRQVPDSASTATAYLC
GVKTNYKTIGLSAAARFDQCNTTFGNEVFSVMYRAKKAGKSVGVVTTTRVQHASPSGTYV
HTVNRNWYGDADMPASALREGCKDIATQLISNMDINVILGGGRKYMFPAGTPDPEYPNDA
NETGTRLDGRNLVQEWLSKHQGSQYVWNREQLIQKAQDPSVTYLMGLFEPVDTKFDIQRD
PLMDPSLKDMTETAVKVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIERA
SQLTSERDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVG
TGERPNVTAAESSGSSYRRQAAVPVKSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVM
ASAGCLEPYTDCGLAPPADESQTTTTTRQTTITTTTTTTTTTTTPVHNSARSLGPATAPL
ALALLAGMLMLLLGAPAES
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BDBM50447413 |
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n/a |
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Name | BDBM50447413 |
Synonyms: | CHEMBL3115157 |
Type | Small organic molecule |
Emp. Form. | C17H17N3O5S |
Mol. Mass. | 375.399 |
SMILES | Cc1ccc(C)c(NC(=O)CNS(=O)(=O)c2ccc3[nH]c(=O)oc3c2)c1 |
Structure |
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