Reaction Details |
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Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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Ligand | BDBM50447442 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1288275 (CHEMBL3117558) |
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IC50 | >100000±n/a nM |
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Citation | Ardecky, RJ; Bobkova, EV; Kiffer-Moreira, T; Brown, B; Ganji, S; Zou, J; Pass, I; Narisawa, S; Iano, FG; Rosenstein, C; Cheltsov, A; Rascon, J; Hedrick, M; Gasior, C; Forster, A; Shi, S; Dahl, R; Vasile, S; Su, Y; Sergienko, E; Chung, TD; Kaunitz, J; Hoylaerts, MF; Pinkerton, AB; Millán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett24:1000-4 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alkaline phosphatase, tissue-nonspecific isozyme |
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Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
Type: | PROTEIN |
Mol. Mass.: | 57306.17 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448917 |
Residue: | 524 |
Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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BDBM50447442 |
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n/a |
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Name | BDBM50447442 |
Synonyms: | CHEMBL3115126 |
Type | Small organic molecule |
Emp. Form. | C20H21N3O7S |
Mol. Mass. | 447.462 |
SMILES | O=C(CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1)NCCCc1ccc2OCOc2c1 |
Structure |
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