Reaction Details |
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Target | Vitamin K-dependent protein C |
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Ligand | BDBM50447519 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1289202 (CHEMBL3119469) |
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Ki | 800±n/a nM |
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Citation | Bach, P; Knerr, L; Fjellström, O; Hansson, K; Mattsson, C; Gustafsson, D Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg Med Chem Lett24:821-7 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin K-dependent protein C |
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Name: | Vitamin K-dependent protein C |
Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
Type: | Enzyme |
Mol. Mass.: | 52067.73 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 461 |
Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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BDBM50447519 |
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n/a |
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Name | BDBM50447519 |
Synonyms: | CHEMBL3115906 |
Type | Small organic molecule |
Emp. Form. | C26H42N8O4 |
Mol. Mass. | 530.6629 |
SMILES | [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#7]-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7] |r| |
Structure |
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