Reaction Details |
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Target | Dual specificity protein kinase TTK |
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Ligand | BDBM50448118 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1291900 (CHEMBL3124214) |
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Ki | 150±n/a nM |
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Citation | Estrada, AA; Chan, BK; Baker-Glenn, C; Beresford, A; Burdick, DJ; Chambers, M; Chen, H; Dominguez, SL; Dotson, J; Drummond, J; Flagella, M; Fuji, R; Gill, A; Halladay, J; Harris, SF; Heffron, TP; Kleinheinz, T; Lee, DW; Le Pichon, CE; Liu, X; Lyssikatos, JP; Medhurst, AD; Moffat, JG; Nash, K; Scearce-Levie, K; Sheng, Z; Shore, DG; Wong, S; Zhang, S; Zhang, X; Zhu, H; Sweeney, ZK Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem57:921-36 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein kinase TTK |
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Name: | Dual specificity protein kinase TTK |
Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
Type: | Protein |
Mol. Mass.: | 97086.79 |
Organism: | Homo sapiens (Human) |
Description: | P33981 |
Residue: | 857 |
Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
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BDBM50448118 |
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n/a |
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Name | BDBM50448118 |
Synonyms: | CHEMBL3122113 | US10590114, No. 80 | US11111235, No. 80 | US11591316, Compound 80 | US9932325, Example 80 |
Type | Small organic molecule |
Emp. Form. | C14H16F3N7 |
Mol. Mass. | 339.3189 |
SMILES | CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F |
Structure |
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