| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50448641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1296518 (CHEMBL3130657) |
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| Kd | >500000±n/a nM |
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| Citation |  Giannetti, AM; Zheng, X; Skelton, NJ; Wang, W; Bravo, BJ; Bair, KW; Baumeister, T; Cheng, E; Crocker, L; Feng, Y; Gunzner-Toste, J; Ho, YC; Hua, R; Liederer, BM; Liu, Y; Ma, X; O'Brien, T; Oeh, J; Sampath, D; Shen, Y; Wang, C; Wang, L; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zhao, Q; Dragovich, PS Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem57:770-92 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM50448641 |
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| n/a |
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| Name | BDBM50448641 |
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| Synonyms: | CHEMBL3127518 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10N2O |
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| Mol. Mass. | 162.1885 |
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| SMILES | O=C(Nc1ccncc1)C1CC1 |
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| Structure | 
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