| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM50448786 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1294756 (CHEMBL3128810) |
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| EC50 | 0.060000±n/a nM |
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| Citation |  Moyes, CR; Berger, R; Goble, SD; Harper, B; Shen, DM; Wang, L; Bansal, A; Brown, PN; Chen, AS; Dingley, KH; Di Salvo, J; Fitzmaurice, A; Gichuru, LN; Hurley, AL; Jochnowitz, N; Miller, RR; Mistry, S; Nagabukuro, H; Salituro, GM; Sanfiz, A; Stevenson, AS; Villa, K; Zamlynny, B; Struthers, M; Weber, AE; Edmondson, SD Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selectiveß3 adrenergic receptor agonists for the treatment of overactive bladder. J Med Chem57:1437-53 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3 | ADRB3_MACMU | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44674.60 |
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| Organism: | Macaca mulatta |
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| Description: | ChEMBL_108044 |
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| Residue: | 418 |
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| Sequence: | MAPWPHGNSSLVPWPDVPTLAPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIV
AITRTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLVLTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRW
ELGRFPPEESSPALSRSLAPAPAGTCAPPEGVPACCRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPDPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CHCGGRLPREPCAADRPASSPRAPLRPGPAPRSPGFASGSTGLLGEFLRPEGQEATLR
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| BDBM50448786 |
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| n/a |
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| Name | BDBM50448786 |
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| Synonyms: | CHEMBL3128194 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N4O2S |
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| Mol. Mass. | 448.58 |
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| SMILES | Nc1nc2[C@@H](CCc2s1)C(=O)Nc1ccc(C[C@@H]2CC[C@@H](N2)[C@H](O)c2ccccc2)cc1 |r| |
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| Structure | 
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