Reaction Details |
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Target | Beta-3 adrenergic receptor |
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Ligand | BDBM50448787 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1294758 (CHEMBL3128845) |
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EC50 | 5.0±n/a nM |
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Citation | Moyes, CR; Berger, R; Goble, SD; Harper, B; Shen, DM; Wang, L; Bansal, A; Brown, PN; Chen, AS; Dingley, KH; Di Salvo, J; Fitzmaurice, A; Gichuru, LN; Hurley, AL; Jochnowitz, N; Miller, RR; Mistry, S; Nagabukuro, H; Salituro, GM; Sanfiz, A; Stevenson, AS; Villa, K; Zamlynny, B; Struthers, M; Weber, AE; Edmondson, SD Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selectiveß3 adrenergic receptor agonists for the treatment of overactive bladder. J Med Chem57:1437-53 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-3 adrenergic receptor |
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Name: | Beta-3 adrenergic receptor |
Synonyms: | ADRB3 | ADRB3_CANLF | B3AR |
Type: | PROTEIN |
Mol. Mass.: | 43072.49 |
Organism: | Canis familiaris |
Description: | ChEMBL_497812 |
Residue: | 405 |
Sequence: | MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIV
AIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRV
GADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRR
ELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGT
FTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
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BDBM50448787 |
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n/a |
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Name | BDBM50448787 |
Synonyms: | CHEMBL3128178 |
Type | Small organic molecule |
Emp. Form. | C24H26N4O2S |
Mol. Mass. | 434.554 |
SMILES | O[C@@H]([C@H]1CC[C@@H](Cc2ccc(NC(=O)[C@@H]3CCc4scnc34)cc2)N1)c1cccnc1 |r| |
Structure |
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