| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 1 |
|---|
| Ligand | BDBM50448923 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1296409 (CHEMBL3130110) |
|---|
| IC50 | 5040±n/a nM |
|---|
| Citation |  Xu, G; Lv, B; Roberge, JY; Xu, B; Du, J; Dong, J; Chen, Y; Peng, K; Zhang, L; Tang, X; Feng, Y; Xu, M; Fu, W; Zhang, W; Zhu, L; Deng, Z; Sheng, Z; Welihinda, A; Sun, X Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes. J Med Chem57:1236-51 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 1 |
|---|
| Name: | Sodium/glucose cotransporter 1 |
|---|
| Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73503.78 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P13866 |
|---|
| Residue: | 664 |
|---|
| Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
|
|
|
|---|
| BDBM50448923 |
|---|
| n/a |
|---|
| Name | BDBM50448923 |
|---|
| Synonyms: | CHEMBL3125316 | CHEMBL3125317 | CHEMBL3125318 | CHEMBL3125455 | CHEMBL3125456 | CHEMBL3125457 | CHEMBL3125458 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25ClO6 |
|---|
| Mol. Mass. | 408.873 |
|---|
| SMILES | CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
