| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50165031 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297748 (CHEMBL3131380) |
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| EC50 | 3100±n/a nM |
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| Citation |  Li, Y; Tian, K; Qin, A; Zhang, L; Huo, L; Lei, L; Shen, Z; Song, H; Feng, Z Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPAR¿. Eur J Med Chem76:182-92 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50165031 |
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| n/a |
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| Name | BDBM50165031 |
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| Synonyms: | 6-({3-isopropoxy-5-[2-(3-thienyl)ethoxy]benzoyl}amino)nicotinic acid | 6-[3-Isopropoxy-5-(2-thiophen-3-yl-ethoxy)-benzoylamino]-nicotinic acid | CHEMBL373339 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N2O5S |
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| Mol. Mass. | 426.485 |
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| SMILES | CC(C)Oc1cc(OCCc2ccsc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O |
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| Structure | 
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