| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit |
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| Ligand | BDBM50015448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1348201 (CHEMBL3270316) |
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| EC50 | 445±n/a nM |
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| Citation |  Currie, KS; Kropf, JE; Lee, T; Blomgren, P; Xu, J; Zhao, Z; Gallion, S; Whitney, JA; Maclin, D; Lansdon, EB; Maciejewski, P; Rossi, AM; Rong, H; Macaluso, J; Barbosa, J; Di Paolo, JA; Mitchell, SA Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. J Med Chem57:3856-73 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit |
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| Name: | Mast/stem cell growth factor receptor Kit |
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| Synonyms: | CD_antigen=CD117 | KIT_MOUSE | Kit | Proto-oncogene c-Kit | SCFR | Sl |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109349.62 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1348201 |
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| Residue: | 979 |
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| Sequence: | MRGARGAWDLLCVLLVLLRGQTATSQPSASPGEPSPPSIHPAQSELIVEAGDTLSLTCID
PDFVRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLTSSIYVFVRDPAKLFL
VGLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPNPKAGITIKNVKRAY
HRLCVRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHLLKKGDTFTVVCTIKDVS
TSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSGVFMCYANNTFG
SANVTTTLKVVEKGFINISPVKNTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSAN
KGKDYVKSDNKSNIRYVNQLRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILT
YDRLINGMLQCVAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSS
IDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMG
IIVMVLTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGA
GAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLL
GACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSS
NEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAK
GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAP
ESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAE
MYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSNLANCNPNPENPVVVDHSVRV
NSVGSSASSTQPLLVHEDA
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| BDBM50015448 |
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| n/a |
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| Name | BDBM50015448 |
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| Synonyms: | CHEMBL3265032 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N7O |
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| Mol. Mass. | 411.4591 |
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| SMILES | C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1 |
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| Structure | 
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