Reaction Details |
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Target | Mast/stem cell growth factor receptor Kit |
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Ligand | BDBM60665 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1348201 (CHEMBL3270316) |
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EC50 | 46±n/a nM |
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Citation | Currie, KS; Kropf, JE; Lee, T; Blomgren, P; Xu, J; Zhao, Z; Gallion, S; Whitney, JA; Maclin, D; Lansdon, EB; Maciejewski, P; Rossi, AM; Rong, H; Macaluso, J; Barbosa, J; Di Paolo, JA; Mitchell, SA Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. J Med Chem57:3856-73 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mast/stem cell growth factor receptor Kit |
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Name: | Mast/stem cell growth factor receptor Kit |
Synonyms: | CD_antigen=CD117 | KIT_MOUSE | Kit | Proto-oncogene c-Kit | SCFR | Sl |
Type: | PROTEIN |
Mol. Mass.: | 109349.62 |
Organism: | Mus musculus |
Description: | ChEMBL_1348201 |
Residue: | 979 |
Sequence: | MRGARGAWDLLCVLLVLLRGQTATSQPSASPGEPSPPSIHPAQSELIVEAGDTLSLTCID
PDFVRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLTSSIYVFVRDPAKLFL
VGLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPNPKAGITIKNVKRAY
HRLCVRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHLLKKGDTFTVVCTIKDVS
TSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSGVFMCYANNTFG
SANVTTTLKVVEKGFINISPVKNTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSAN
KGKDYVKSDNKSNIRYVNQLRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILT
YDRLINGMLQCVAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSS
IDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMG
IIVMVLTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGA
GAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLL
GACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSS
NEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAK
GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAP
ESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAE
MYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSNLANCNPNPENPVVVDHSVRV
NSVGSSASSTQPLLVHEDA
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BDBM60665 |
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n/a |
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Name | BDBM60665 |
Synonyms: | BDBM50249542 | US9145414, R406 | US9212178, R406 |
Type | n/a |
Emp. Form. | C22H23FN6O5 |
Mol. Mass. | 470.4536 |
SMILES | COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC |
Structure |
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