Reaction Details |
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Target | 5-hydroxytryptamine receptor 2C |
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Ligand | BDBM50019691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1361180 |
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Ki | 38±n/a nM |
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Citation | Storer, RI; Brennan, PE; Brown, AD; Bungay, PJ; Conlon, KM; Corbett, MS; DePianta, RP; Fish, PV; Heifetz, A; Ho, DK; Jessiman, AS; McMurray, G; de Oliveira, CA; Roberts, LR; Root, JA; Shanmugasundaram, V; Shapiro, MJ; Skerten, M; Westbrook, D; Wheeler, S; Whitlock, GA; Wright, J Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors. J Med Chem57:5258-69 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2C |
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Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51836.79 |
Organism: | Homo sapiens (Human) |
Description: | P28335 |
Residue: | 458 |
Sequence: | MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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BDBM50019691 |
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n/a |
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Name | BDBM50019691 |
Synonyms: | CHEMBL3286565 |
Type | Small organic molecule |
Emp. Form. | C17H22N4 |
Mol. Mass. | 282.3834 |
SMILES | CNc1nc(nc2CCNCCc12)C(C)c1ccccc1 |
Structure |
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