Reaction Details |
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Target | Fatty-acid amide hydrolase 1 [30-579] |
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Ligand | BDBM50021331 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1366316 (CHEMBL3295962) |
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IC50 | 10.0±n/a nM |
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Citation | Chobanian, HR; Guo, Y; Liu, P; Chioda, MD; Fung, S; Lanza, TJ; Chang, L; Bakshi, RK; Dellureficio, JP; Hong, Q; McLaughlin, M; Belyk, KM; Krska, SW; Makarewicz, AK; Martel, EJ; Leone, JF; Frey, L; Karanam, B; Madeira, M; Alvaro, R; Shuman, J; Salituro, G; Terebetski, JL; Jochnowitz, N; Mistry, S; McGowan, E; Hajdu, R; Rosenbach, M; Abbadie, C; Alexander, JP; Shiao, LL; Sullivan, KM; Nargund, RP; Wyvratt, MJ; Lin, LS; DeVita, RJ Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain. ACS Med Chem Lett5:717-21 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Fatty-acid amide hydrolase 1 [30-579] |
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Name: | Fatty-acid amide hydrolase 1 [30-579] |
Synonyms: | Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1 |
Type: | Single-pass membrane protein; homodimer |
Mol. Mass.: | 60474.00 |
Organism: | Rattus norvegicus (rat) |
Description: | P97612 (aa 30-579) |
Residue: | 550 |
Sequence: | RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSG
ELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKG
HDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWK
SSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGC
VYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGY
YETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFL
QNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQH
EIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPV
TTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVE
QLMTPQKQPS
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BDBM50021331 |
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n/a |
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Name | BDBM50021331 |
Synonyms: | CHEMBL3287930 |
Type | Small organic molecule |
Emp. Form. | C22H18ClFN4OS |
Mol. Mass. | 440.921 |
SMILES | CC(C)(O)c1cnc(cn1)-c1nn(cc1Sc1ccc(Cl)cc1)-c1ccc(F)cc1 |
Structure |
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