| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase alpha-3 |
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| Ligand | BDBM50021681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1368328 (CHEMBL868674) |
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| IC50 | >20000±n/a nM |
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| Citation |  Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors. Bioorg Med Chem Lett24:1592-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase alpha-3 |
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| Name: | Ribosomal protein S6 kinase alpha-3 |
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| Synonyms: | 90 kDa ribosomal protein S6 kinase 3 | ISPK-1 | ISPK1 | KS6A3_HUMAN | MAP kinase-activated protein kinase 1b | MAPKAPK1B | RPS6KA3 | RPS6KA3(Kin.Dom.1 - N-terminal) | RSK2 | Ribosomal S6 kinase 2 (RSK2) | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha-1/alpha-3 | Ribosomal protein S6 kinase alpha-3 (RSK2) | Ribosomal protein S6 kinase alpha-3 (RSK3) | S6K-alpha 3 | insulin-stimulated protein kinase 1 | p90 ribosomal s6 kinase (RSK2) | p90-RSK 3 | p90RSK | pp90RSK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 83740.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The human RSK2 sequence differed from the Genbank entry NM_004586 at one residue, V45G. The protein was cloned and purified from baculovirus expression system. |
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| Residue: | 740 |
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| Sequence: | MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH
EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD
ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV
NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR
MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD
GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL
KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD
IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP
VGRSTLAQRRGIKKITSTAL
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| BDBM50021681 |
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| n/a |
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| Name | BDBM50021681 |
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| Synonyms: | CHEMBL3297841 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11FN2O2 |
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| Mol. Mass. | 258.2477 |
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| SMILES | COc1cccc(F)c1-c1cccc2nc(N)oc12 |(16.32,-19.52,;14.99,-18.76,;13.65,-19.53,;13.66,-21.07,;12.32,-21.85,;10.98,-21.08,;10.99,-19.54,;9.65,-18.76,;12.32,-18.77,;12.32,-17.23,;13.66,-16.46,;13.65,-14.91,;12.32,-14.14,;10.99,-14.92,;9.52,-14.44,;8.62,-15.68,;7.08,-15.68,;9.52,-16.93,;10.99,-16.46,)| |
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| Structure | 
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