Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
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Ligand | BDBM50323721 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1436364 (CHEMBL3389567) |
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Kd | 3.1±n/a nM |
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Citation | Fu, J; Tjandra, M; Becker, C; Bednarczyk, D; Capparelli, M; Elling, R; Hanna, I; Fujimoto, R; Furegati, M; Karur, S; Kasprzyk, T; Knapp, M; Leung, K; Li, X; Lu, P; Mergo, W; Miault, C; Ng, S; Parker, D; Peng, Y; Roggo, S; Rivkin, A; Simmons, RL; Wang, M; Wiedmann, B; Weiss, AH; Xiao, L; Xie, L; Xu, W; Yifru, A; Yang, S; Zhou, B; Sweeney, ZK Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. J Med Chem57:8503-16 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
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Name: | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
Synonyms: | CYP3 | CyP-D | CyP-M | Cyclophilin D | Cyclophilin F | CypD | Mitochondrial cyclophilin | PPIF | PPIF_HUMAN | PPIase F | Rotamase F |
Type: | PROTEIN |
Mol. Mass.: | 22052.60 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109465 |
Residue: | 207 |
Sequence: | MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLG
RVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSI
YGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDV
VKKIESFGSKSGRTSKKIVITDCGQLS
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BDBM50323721 |
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n/a |
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Name | BDBM50323721 |
Synonyms: | (3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(dimethylamino)ethylthio)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-enyl)-24-(2-hydroxy-2-methylpropyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone | CHEMBL1213341 | SCY-635 |
Type | Small organic molecule |
Emp. Form. | C66H120N12O13S |
Mol. Mass. | 1321.797 |
SMILES | CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)(C)O)N(C)C(=O)[C@H](SCCN(C)C)N(C)C1=O)C(C)C |r| |
Structure |
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