| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SUV39H1 |
|---|
| Ligand | BDBM50031317 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1436394 (CHEMBL3389597) |
|---|
| IC50 | >150000±n/a nM |
|---|
| Citation |  Chen, S; Wang, Y; Zhou, W; Li, S; Peng, J; Shi, Z; Hu, J; Liu, YC; Ding, H; Lin, Y; Li, L; Cheng, S; Liu, J; Lu, T; Jiang, H; Liu, B; Zheng, M; Luo, C Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem57:9028-41 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-lysine N-methyltransferase SUV39H1 |
|---|
| Name: | Histone-lysine N-methyltransferase SUV39H1 |
|---|
| Synonyms: | H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | KMT1A | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | SUV39H | SUV39H1 | SUV91_HUMAN | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47917.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1473655 |
|---|
| Residue: | 412 |
|---|
| Sequence: | MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYY
LVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQ
KAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVG
CECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKG
IRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFD
LDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEE
LTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
|
|
|
|---|
| BDBM50031317 |
|---|
| n/a |
|---|
| Name | BDBM50031317 |
|---|
| Synonyms: | CHEMBL3358015 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25N3O |
|---|
| Mol. Mass. | 383.4855 |
|---|
| SMILES | OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
