Compile Data Set for Download or QSAR

Found 22 hits Enz. Inhib. hit(s) with all data for entry = 50044814   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031315 (CHEMBL3358028) Show SMILES CC(C)NCC(O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031320 (CHEMBL3358030) Show SMILES CC(C)NC[C@H](O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12 |r| Show InChI InChI=1S/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM43255 (1-(3,6-dichloro-9-carbazolyl)-3-[2-(3H-indol-3-yl)...) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12 Show InChI InChI=1S/C25H23Cl2N3O/c26-17-5-7-24-21(11-17)22-12-18(27)6-8-25(22)30(24)15-19(31)14-28-10-9-16-13-29-23-4-2-1-3-20(16)23/h1-8,11-13,19,28-29,31H,9-10,14-15H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031321 (CHEMBL3358029) Show SMILES CC(C)NC[C@@H](O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12 |r| Show InChI InChI=1S/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3/t24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031331 (CHEMBL3358016) Show SMILES O[C@H](CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031325 (CHEMBL3358023) Show SMILES OCCNCC(O)Cn1c2ccc(Br)cc2c2cc(Br)ccc12 Show InChI InChI=1S/C17H18Br2N2O2/c18-11-1-3-16-14(7-11)15-8-12(19)2-4-17(15)21(16)10-13(23)9-20-5-6-22/h1-4,7-8,13,20,22-23H,5-6,9-10H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031329 (CHEMBL3358017) Show SMILES O[C@@H](CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 |r| Show InChI InChI=1S/C25H25N3O/c29-19(16-26-14-13-18-15-27-23-10-4-1-7-20(18)23)17-28-24-11-5-2-8-21(24)22-9-3-6-12-25(22)28/h1-12,15,19,26-27,29H,13-14,16-17H2/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031328 (CHEMBL3358020) Show SMILES OC(CNCCc1ccccc1)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C23H24N2O/c26-19(16-24-15-14-18-8-2-1-3-9-18)17-25-22-12-6-4-10-20(22)21-11-5-7-13-23(21)25/h1-13,19,24,26H,14-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031327 (CHEMBL3358021) Show SMILES COCCNCC(O)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C18H22N2O2/c1-22-11-10-19-12-14(21)13-20-17-8-4-2-6-15(17)16-7-3-5-9-18(16)20/h2-9,14,19,21H,10-13H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.96E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371] (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.71E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of PRMT1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031322 (CHEMBL3358027) Show SMILES CC(C)(CO)CC(O)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C19H23NO2/c1-19(2,13-21)11-14(22)12-20-17-9-5-3-7-15(17)16-8-4-6-10-18(16)20/h3-10,14,21-22H,11-13H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031318 (CHEMBL1911321) Show SMILES OC(CNCc1ccccc1)Cn1c2CCCCc2c2ccccc12 Show InChI InChI=1S/C22H26N2O/c25-18(15-23-14-17-8-2-1-3-9-17)16-24-21-12-6-4-10-19(21)20-11-5-7-13-22(20)24/h1-4,6,8-10,12,18,23,25H,5,7,11,13-16H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031323 (CHEMBL1557883) Show SMILES CC1CCN(CC(O)Cn2c3ccccc3c3ccccc23)CC1 Show InChI InChI=1S/C21H26N2O/c1-16-10-12-22(13-11-16)14-17(24)15-23-20-8-4-2-6-18(20)19-7-3-5-9-21(19)23/h2-9,16-17,24H,10-15H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EHMT2 (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of G9a (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase 2A (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of MLL1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of SET7/9 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SUV39H1 (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of SUV39H1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 3B (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of DNMT3B (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 3A (Homo sapiens (Human))	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of DNMT3A (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ...				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031317 (CHEMBL3358015) Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (Mus musculus)	BDBM50031315 (CHEMBL3358028) Show SMILES CC(C)NCC(O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assay				J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6
					More data for this Ligand-Target Pair