Reaction Details |
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Target | Cathepsin E |
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Ligand | BDBM50031612 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1442517 (CHEMBL3371641) |
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IC50 | 320±n/a nM |
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Citation | Dineen, TA; Chen, K; Cheng, AC; Derakhchan, K; Epstein, O; Esmay, J; Hickman, D; Kreiman, CE; Marx, IE; Wahl, RC; Wen, PH; Weiss, MM; Whittington, DA; Wood, S; Fremeau, RT; White, RD; Patel, VF Inhibitors of฿-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718). J Med Chem57:9811-31 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin E |
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Name: | Cathepsin E |
Synonyms: | 3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II |
Type: | Enzyme |
Mol. Mass.: | 43298.99 |
Organism: | Homo sapiens (Human) |
Description: | P14091 |
Residue: | 396 |
Sequence: | MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
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BDBM50031612 |
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n/a |
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Name | BDBM50031612 |
Synonyms: | CHEMBL3354688 |
Type | Small organic molecule |
Emp. Form. | C24H24N4O3 |
Mol. Mass. | 416.4724 |
SMILES | CC(C)(C)COc1ccc2Oc3ccc(cc3[C@@]3(COC(N)=N3)c2c1)-c1cncnc1 |r,c:22| |
Structure |
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