| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50036657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1434404 (CHEMBL3387656) |
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| EC50 | 15±n/a nM |
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| Citation |  Azimioara, M; Alper, P; Cow, C; Mutnick, D; Nikulin, V; Lelais, G; Mecom, J; McNeill, M; Michellys, PY; Wang, Z; Reding, E; Paliotti, M; Li, J; Bao, D; Zoll, J; Kim, Y; Zimmerman, M; Groessl, T; Tuntland, T; Joseph, SB; McNamara, P; Seidel, HM; Epple, R Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorg Med Chem Lett24:5478-83 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | GP119_MOUSE | Gpr119 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37009.07 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1506420 |
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| Residue: | 335 |
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| Sequence: | MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISG
LVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGL
VAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLL
FVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSP
FLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKF
FTSILLLLPARNRGPERTRESAYHIVTISHPELDG
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| BDBM50036657 |
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| n/a |
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| Name | BDBM50036657 |
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| Synonyms: | CHEMBL3354788 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18F3N3O3 |
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| Mol. Mass. | 453.4132 |
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| SMILES | COC(=O)C1(Cc2ccccc2)COc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F |
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| Structure | 
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