Reaction Details |
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Target | Histone-lysine N-methyltransferase KMT5B |
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Ligand | BDBM50051117 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1450373 (CHEMBL3378210) |
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IC50 | >100000±n/a nM |
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Citation | Ma, A; Yu, W; Li, F; Bleich, RM; Herold, JM; Butler, KV; Norris, JL; Korboukh, V; Tripathy, A; Janzen, WP; Arrowsmith, CH; Frye, SV; Vedadi, M; Brown, PJ; Jin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem57:6822-33 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone-lysine N-methyltransferase KMT5B |
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Name: | Histone-lysine N-methyltransferase KMT5B |
Synonyms: | Histone-lysine N-methyltransferase SUV420H1 | KMT5B | KMT5B_HUMAN | Lysine N-methyltransferase 5B | Protein lysine methyltransferase SUV4-20H1 (SUV4-20H1) | SUV420H1 | Su(var)4-20 homolog 1 | Suppressor of variegation 4-20 homolog 1 | Suv4-20h1 |
Type: | Enzyme |
Mol. Mass.: | 99219.53 |
Organism: | Homo sapiens (Human) |
Description: | Q4FZB7 |
Residue: | 885 |
Sequence: | MKWLGESKNMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTLKAGKNAVERRSNRCNGNSGF
EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHFSKSDSFS
HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE
HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN
MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG
EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR
LKKLGDSSKNSDSQSVSSNTDADTTQEKNNATSNRKSSVGVKKNSKSRTLTRQSMSRIPA
SSNSTSSKLTHINNSRVPKKLKKPAKPLLSKIKLRNHCKRLEQKNASRKLEMGNLVLKEP
KVVLYKNLPIKKDKEPEGPAQAAVASGCLTRHAAREHRQNPVRGAHSQGESSPCTYITRR
SVRTRTNLKEASDIKLEPNTLNGYKSSVTEPCPDSGEQLQPAPVLQEEELAHETAQKGEA
KCHKSDTGMSKKKSRQGKLVKQFAKIEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVG
VPVSYTDCAPSPVGCSVVTSDSFKTKDSFRTAKSKKKRRITRYDAQLILENNSGIPKLTL
RRRHDSSSKTNDQENDGMNSSKISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQ
LKRDEENRGSYTEGLHENGVCCSDPLSLLESRMEVDDYSQYEEESTDDSSSSEGDEEEDD
YDDDFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
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BDBM50051117 |
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n/a |
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Name | BDBM50051117 |
Synonyms: | CHEMBL3318285 |
Type | Small organic molecule |
Emp. Form. | C23H35N5O2 |
Mol. Mass. | 413.5563 |
SMILES | COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1 |
Structure |
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