Reaction Details |
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Target | Peroxisome proliferator-activated receptor alpha |
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Ligand | BDBM50063219 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1463126 (CHEMBL3399109) |
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IC50 | 3250±n/a nM |
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Citation | Zhang, H; Ding, CZ; Lai, Z; Chen, SS; Devasthale, P; Herpin, T; Morton, G; Qu, F; Ryono, D; Smirk, R; Wang, W; Wu, S; Ye, XX; Li, YX; Apedo, A; Farrelly, D; Wang, T; Gu, L; Morgan, N; Flynn, N; Chu, C; Kunselman, L; Lippy, J; Locke, K; O'Malley, K; Harrity, T; Cap, M; Zhang, L; Hosagrahara, V; Kadiyala, P; Xu, C; Doweyko, AM; Zahler, R; Hariharan, N; Cheng, PT Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists. Bioorg Med Chem Lett25:1196-205 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peroxisome proliferator-activated receptor alpha |
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Name: | Peroxisome proliferator-activated receptor alpha |
Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
Type: | Enzyme |
Mol. Mass.: | 52222.08 |
Organism: | Homo sapiens (Human) |
Description: | Q07869 |
Residue: | 468 |
Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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BDBM50063219 |
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n/a |
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Name | BDBM50063219 |
Synonyms: | CHEMBL3398461 |
Type | Small organic molecule |
Emp. Form. | C32H32N2O6 |
Mol. Mass. | 540.6063 |
SMILES | Cc1oc(nc1CCOc1ccc(CC[C@H]2CN(C[C@@H]2C(O)=O)C(=O)Oc2ccccc2)cc1)-c1ccccc1 |r| |
Structure |
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