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TargetPeroxisome proliferator-activated receptor alpha
LigandBDBM50063308
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463127 (CHEMBL3399110)
EC50>15000±n/a nM
Citation Zhang, HDing, CZLai, ZChen, SSDevasthale, PHerpin, TMorton, GQu, FRyono, DSmirk, RWang, WWu, SYe, XXLi, YXApedo, AFarrelly, DWang, TGu, LMorgan, NFlynn, NChu, CKunselman, LLippy, JLocke, KO'Malley, KHarrity, TCap, MZhang, LHosagrahara, VKadiyala, PXu, CDoweyko, AMZahler, RHariharan, NCheng, PT Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists. Bioorg Med Chem Lett25:1196-205 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor alpha
Name:Peroxisome proliferator-activated receptor alpha
Synonyms:NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:Enzyme
Mol. Mass.:52222.08
Organism:Homo sapiens (Human)
Description:Q07869
Residue:468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50063308
n/a
NameBDBM50063308
Synonyms:CHEMBL3398435
TypeSmall organic molecule
Emp. Form.C31H30N2O6
Mol. Mass.526.5797
SMILESCc1oc(nc1CCOc1ccc(cc1)[C@@H]1CN(C[C@@H]1CC(O)=O)C(=O)Oc1ccccc1)-c1ccccc1 |r|
Structure
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