| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50066161 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1465587 (CHEMBL3404889) |
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| IC50 | 15±n/a nM |
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| Citation |  Lorthiois, E; Cumin, F; Ehrhardt, C; Kosaka, T; Sellner, H; Ostermann, N; Francotte, E; Wagner, T; Maibaum, J trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker. Bioorg Med Chem Lett25:1782-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50066161 |
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| n/a |
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| Name | BDBM50066161 |
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| Synonyms: | CHEMBL3400452 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H43N3O6 |
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| Mol. Mass. | 541.6789 |
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| SMILES | CC[C@@H](OC(=O)N[C@@H]1CNC[C@H]1CN(C(C)C)C(=O)c1ccc(OC)c(OCCCOC)c1)c1ccccc1 |r| |
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| Structure | 
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