Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetReverse transcriptase
LigandBDBM50075214
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473739
IC50 2800±n/a nM
Citation Vernekar SKLiu ZNagy EMiller LKirby KAWilson DJKankanala JSarafianos SGParniak MAWang Z Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem 58:651-64 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase
Name:Reverse transcriptase
Synonyms:n/a
Type:Protein
Mol. Mass.:29598.37
Organism:Human immunodeficiency virus 1
Description:Q9WKE8
Residue:254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50075214
n/a
NameBDBM50075214
Synonyms:CHEMBL3414876
TypeSmall organic molecule
Emp. Form.C28H24N2O6S
Mol. Mass.516.565
SMILESCc1ccc(cc1)S([O-])(=O)=O.ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cc[nH+]cc3)ccc2C1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: