Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM50075211 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1473731 (CHEMBL3418037) |
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IC50 | 1700±n/a nM |
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Citation | Vernekar, SK; Liu, Z; Nagy, E; Miller, L; Kirby, KA; Wilson, DJ; Kankanala, J; Sarafianos, SG; Parniak, MA; Wang, Z Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem58:651-64 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM50075211 |
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n/a |
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Name | BDBM50075211 |
Synonyms: | CHEMBL3414857 |
Type | Small organic molecule |
Emp. Form. | C16H13NO3 |
Mol. Mass. | 267.2793 |
SMILES | ON1C(=O)Cc2cc(Cc3ccccc3)ccc2C1=O |
Structure |
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