| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50075454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473818 (CHEMBL3418717) |
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| IC50 | 84±n/a nM |
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| Citation |  Park, JH; Lee, GE; Lee, SD; Hien, TT; Kim, S; Yang, JW; Cho, JH; Ko, H; Lim, SC; Kim, YG; Kang, KW; Kim, YC Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. J Med Chem58:2114-34 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50075454 |
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| n/a |
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| Name | BDBM50075454 |
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| Synonyms: | CHEMBL3415330 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H40N4O6S |
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| Mol. Mass. | 656.791 |
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| SMILES | O=C(CC12CC3CC(CC(C3)C1)C2)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O |TLB:12:3:10:6.7.8,THB:8:7:4:10.9.11,8:9:6.7.12:4,12:7:10:3.4.11,2:3:10:6.7.8| |
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| Structure | 
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