| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50078029 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1471768 (CHEMBL3417879) |
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| Ki | 3400±n/a nM |
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| Citation |  Stornaiuolo, M; La Regina, G; Passacantilli, S; Grassia, G; Coluccia, A; La Pietra, V; Giustiniano, M; Cassese, H; Di Maro, S; Brancaccio, D; Taliani, S; Ialenti, A; Silvestri, R; Martini, C; Novellino, E; Marinelli, L Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents. J Med Chem58:2135-48 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50078029 |
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| n/a |
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| Name | BDBM50078029 |
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| Synonyms: | CHEMBL3417409 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25N5O2 |
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| Mol. Mass. | 463.5304 |
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| SMILES | CN(C)c1ccc(cc1)-c1cc(O)cc(c1)N1N=C(C)\C(=N\Nc2ccc3ccccc3c2)C1=O |t:19| |
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| Structure | 
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