| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hepatocyte growth factor receptor |
|---|
| Ligand | BDBM24469 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1470881 (CHEMBL3418289) |
|---|
| IC50 | 2100±n/a nM |
|---|
| Citation |  Peterson, EA; Teffera, Y; Albrecht, BK; Bauer, D; Bellon, SF; Boezio, A; Boezio, C; Broome, MA; Choquette, D; Copeland, KW; Dussault, I; Lewis, R; Lin, MH; Lohman, J; Liu, J; Potashman, M; Rex, K; Shimanovich, R; Whittington, DA; Vaida, KR; Harmange, JC Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors. J Med Chem58:2417-30 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hepatocyte growth factor receptor |
|---|
| Name: | Hepatocyte growth factor receptor |
|---|
| Synonyms: | Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 155559.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08581 |
|---|
| Residue: | 1390 |
|---|
| Sequence: | MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS
|
|
|
|---|
| BDBM24469 |
|---|
| n/a |
|---|
| Name | BDBM24469 |
|---|
| Synonyms: | 4-({6-phenyl-[1,2,4]triazolo[3,4-a]pyridin-3-yl}methyl)phenol | 4-[(6-phenyl[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl]phenol | Triazolopyridine, 3c | US9066954, 66 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H15N3O |
|---|
| Mol. Mass. | 301.3419 |
|---|
| SMILES | Oc1ccc(Cc2nnc3ccc(cn23)-c2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
