| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Ligand | BDBM50090918 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1499159 (CHEMBL3585165) |
|---|
| IC50 | 37000±n/a nM |
|---|
| Citation |  Beck, DE; Abdelmalak, M; Lv, W; Reddy, PV; Tender, GS; O'Neill, E; Agama, K; Marchand, C; Pommier, Y; Cushman, M Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore. J Med Chem58:3997-4015 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Name: | Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68430.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NUW8 |
|---|
| Residue: | 608 |
|---|
| Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
|
|
|
|---|
| BDBM50090918 |
|---|
| n/a |
|---|
| Name | BDBM50090918 |
|---|
| Synonyms: | CHEMBL3581877 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N3O2 |
|---|
| Mol. Mass. | 333.3838 |
|---|
| SMILES | CN(C)CCCn1c2-c3ccccc3C(=O)c2c2ccncc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
