| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 |
|---|
| Ligand | BDBM50090917 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1499160 (CHEMBL3585166) |
|---|
| IC50 | >111000±n/a nM |
|---|
| Citation |  Beck, DE; Abdelmalak, M; Lv, W; Reddy, PV; Tender, GS; O'Neill, E; Agama, K; Marchand, C; Pommier, Y; Cushman, M Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore. J Med Chem58:3997-4015 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosyl-DNA phosphodiesterase 2 |
|---|
| Name: | Tyrosyl-DNA phosphodiesterase 2 |
|---|
| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 40916.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_23510348 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
|
|
|
|---|
| BDBM50090917 |
|---|
| n/a |
|---|
| Name | BDBM50090917 |
|---|
| Synonyms: | CHEMBL3581863 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14INO4 |
|---|
| Mol. Mass. | 447.2232 |
|---|
| SMILES | OC[C@@H](O)Cn1c2-c3ccccc3C(=O)c2c2ccc(I)cc2c1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
