Reaction Details | |||
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Target | Nociceptin receptor | ||
Ligand | BDBM50100995 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1452449 (CHEMBL3362473) | ||
Ki | 110±n/a nM | ||
Citation | Schunk, S; Linz, K; Frormann, S; Hinze, C; Oberbörsch, S; Sundermann, B; Zemolka, S; Englberger, W; Germann, T; Christoph, T; Kögel, BY; Schröder, W; Harlfinger, S; Saunders, D; Kless, A; Schick, H; Sonnenschein, H Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists. ACS Med Chem Lett5:851-6 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nociceptin receptor | |||
Name: | Nociceptin receptor | ||
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 40702.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41146 | ||
Residue: | 370 | ||
Sequence: |
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BDBM50100995 | |||
n/a | |||
Name | BDBM50100995 | ||
Synonyms: | CHEMBL3325883 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H31ClN2 | ||
Mol. Mass. | 322.916 | ||
SMILES | Cl.CN(C)[C@@]1(CC[C@@H](CC1)N1CCCCC1)c1ccccc1 |r,wU:7.9,4.2,(16.33,-31.4,;12.7,-28.27,;11.36,-27.51,;11.36,-25.97,;10.03,-28.28,;9.26,-26.95,;7.72,-26.95,;6.95,-28.29,;7.72,-29.61,;9.26,-29.61,;5.41,-28.29,;4.64,-26.96,;3.1,-26.95,;2.32,-28.29,;3.09,-29.63,;4.64,-29.63,;10.83,-29.6,;10.08,-30.94,;10.88,-32.26,;12.42,-32.23,;13.16,-30.87,;12.36,-29.56,)| | ||
Structure |