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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nociceptin receptor | ||
| Ligand | BDBM50101161 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1453323 (CHEMBL3366607) | ||
| Ki | 3.7±n/a nM | ||
| Citation |  Schunk, S; Linz, K; Hinze, C; Frormann, S; Oberbörsch, S; Sundermann, B; Zemolka, S; Englberger, W; Germann, T; Christoph, T; Kögel, BY; Schröder, W; Harlfinger, S; Saunders, D; Kless, A; Schick, H; Sonnenschein, H Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol. ACS Med Chem Lett5:857-62 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nociceptin receptor | |||
| Name: | Nociceptin receptor | ||
| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40702.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41146 | ||
| Residue: | 370 | ||
| Sequence: |
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| BDBM50101161 | |||
| n/a | |||
| Name | BDBM50101161 | ||
| Synonyms: | CHEMBL3326230 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H36N2O7S | ||
| Mol. Mass. | 568.681 | ||
| SMILES | OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)[C@]1(CC[C@@]2(CC1)SCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:16.14,wD:19.21,(18.17,-16.09,;19.49,-16.85,;20.81,-16.09,;19.49,-18.38,;18.17,-19.15,;16.84,-18.38,;18.92,-20.47,;20.45,-20.47,;21.21,-21.8,;21.22,-19.15,;17.4,-20.46,;18.16,-21.79,;15.87,-20.46,;11.7,-23.69,;10.22,-24.1,;9.12,-23.01,;9.82,-25.6,;9.05,-26.92,;7.52,-26.92,;6.75,-25.59,;7.52,-24.26,;9.06,-24.26,;5.84,-26.85,;4.3,-26.69,;3.67,-25.27,;4.58,-24.02,;6.12,-24.18,;6.75,-22.77,;5.61,-21.73,;5.6,-20.17,;4.26,-19.41,;2.93,-20.18,;2.93,-21.73,;4.26,-22.5,;11.36,-25.6,;12.12,-26.95,;13.66,-26.96,;14.44,-25.62,;13.67,-24.28,;12.13,-24.28,)| | ||
| Structure | 
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