| Reaction Details |
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 | Report a problem with these data |
| Target | Prostacyclin receptor |
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| Ligand | BDBM50103393 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1463659 (CHEMBL3399046) |
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| EC50 | 260±n/a nM |
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| Citation |  Tran, TA; Shin, YJ; Kramer, B; Choi, J; Zou, N; Vallar, P; Martens, P; Boatman, PD; Adams, JW; Ramirez, J; Shi, Y; Morgan, M; Unett, DJ; Chang, S; Shu, HH; Tung, SF; Semple, G Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat. Bioorg Med Chem Lett25:1030-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostacyclin receptor |
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| Name: | Prostacyclin receptor |
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| Synonyms: | PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40968.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The membranes prepared from human platelet were used in binding assay. |
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| Residue: | 386 |
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| Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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| BDBM50103393 |
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| n/a |
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| Name | BDBM50103393 |
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| Synonyms: | CHEMBL3398231 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25FN2O4 |
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| Mol. Mass. | 484.5182 |
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| SMILES | OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4cccc(F)c4)c3=O)CCc12 |
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| Structure | 
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