| Reaction Details |
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 | Report a problem with these data |
| Target | Prostacyclin receptor |
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| Ligand | BDBM50103436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1463661 (CHEMBL3399048) |
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| EC50 | 2370±n/a nM |
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| Citation |  Tran, TA; Shin, YJ; Kramer, B; Choi, J; Zou, N; Vallar, P; Martens, P; Boatman, PD; Adams, JW; Ramirez, J; Shi, Y; Morgan, M; Unett, DJ; Chang, S; Shu, HH; Tung, SF; Semple, G Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat. Bioorg Med Chem Lett25:1030-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostacyclin receptor |
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| Name: | Prostacyclin receptor |
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| Synonyms: | PI2R_RAT | Prostacyclin receptor | Prostaglandin I2 | Ptgir |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44673.87 |
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| Organism: | RAT |
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| Description: | Prostaglandin I2 PTGIR RAT::P43253 |
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| Residue: | 416 |
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| Sequence: | MVASGGRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGN
GLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTML
CDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCCLFC
SLPLLGLGEHQQYCPGSWCFIRMRSPQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLC
HMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTGIMAVCSLPLTIRGFTQAIAPDSREM
GDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQTPLSRPVSGRRD
TLAPDSLQAKEGNWVPLSTWGTGQVAPLTAVPLSGGDGCSVGMPSKTEAVVACSLC
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| BDBM50103436 |
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| n/a |
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| Name | BDBM50103436 |
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| Synonyms: | CHEMBL3398214 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25FN2O4 |
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| Mol. Mass. | 484.5182 |
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| SMILES | OC(=O)COc1cccc2CC(Cn3nc(-c4cccc(F)c4)c(cc3=O)-c3ccccc3)CCc12 |
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| Structure | 
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