Reaction Details |
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Target | Serine/threonine-protein kinase TNNI3K |
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Ligand | BDBM50118389 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1514933 (CHEMBL3615799) |
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IC50 | 500±n/a nM |
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Citation | Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K). J Med Chem58:7431-48 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase TNNI3K |
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Name: | Serine/threonine-protein kinase TNNI3K |
Synonyms: | CARK | Serine/threonine-protein kinase TNNI3K | TNI3K_HUMAN | TNNI3K |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 92855.14 |
Organism: | Homo sapiens (Human) |
Description: | gi_7705748 |
Residue: | 835 |
Sequence: | MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE
QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH
FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK
ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL
DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG
GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG
RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ
YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG
HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT
GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE
ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA
LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
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BDBM50118389 |
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n/a |
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Name | BDBM50118389 |
Synonyms: | CHEMBL3612641 |
Type | Small organic molecule |
Emp. Form. | C12H12N6O2S |
Mol. Mass. | 304.328 |
SMILES | CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cnc23)c1 |
Structure |
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