| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50127245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1522303 (CHEMBL3630726) |
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| IC50 | 439±n/a nM |
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| Citation |  Kaminska, K; Ziemba, J; Ner, J; Schwed, JS; Lazewska, D; Wiecek, M; Karcz, T; Olejarz, A; Latacz, G; Kuder, K; Kottke, T; Zygmunt, M; Sapa, J; Karolak-Wojciechowska, J; Stark, H; Kiec-Kononowicz, K (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands. Eur J Med Chem103:238-51 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50127245 |
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| n/a |
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| Name | BDBM50127245 |
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| Synonyms: | CHEMBL3628042 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19ClN6 |
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| Mol. Mass. | 330.815 |
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| SMILES | CN1CCN(CC1)c1nc(N)nc(\C=C\c2cccc(Cl)c2)n1 |
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| Structure | 
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