| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase tousled-like 1 |
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| Ligand | BDBM50154291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1560702 (CHEMBL3778053) |
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| IC50 | <5000±n/a nM |
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| Citation |  Shchekotikhin, AE; Dezhenkova, LG; Tsvetkov, VB; Luzikov, YN; Volodina, YL; Tatarskiy, VV; Kalinina, AA; Treshalin, MI; Treshalina, HM; Romanenko, VI; Kaluzhny, DN; Kubbutat, M; Schols, D; Pommier, Y; Shtil, AA; Preobrazhenskaya, MN Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties. Eur J Med Chem112:114-29 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase tousled-like 1 |
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| Name: | Serine/threonine-protein kinase tousled-like 1 |
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| Synonyms: | KIAA0137 | Serine/threonine-protein kinase tousled-like 1 | TLK1 | TLK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86722.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_33636698 |
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| Residue: | 766 |
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| Sequence: | MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ
ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS
RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP
SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID
DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL
GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP
STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE
LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR
YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY
CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC
GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV
GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE
DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
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| BDBM50154291 |
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| n/a |
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| Name | BDBM50154291 |
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| Synonyms: | CHEMBL3775181 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N2O9S |
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| Mol. Mass. | 502.494 |
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| SMILES | CS(O)(=O)=O.Cc1oc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c2c1C(=O)N1CC[C@H](N)C1 |r| |
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| Structure | 
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