| Reaction Details |
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 | Report a problem with these data |
| Target | Discoidin domain-containing receptor 2 |
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| Ligand | BDBM50156123 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1563168 (CHEMBL3783997) |
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| IC50 | 457±n/a nM |
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| Citation |  Liang, X; Liu, X; Wang, B; Zou, F; Wang, A; Qi, S; Chen, C; Zhao, Z; Wang, W; Qi, Z; Lv, F; Hu, Z; Wang, L; Zhang, S; Liu, Q; Liu, J Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia. J Med Chem59:1984-2004 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Discoidin domain-containing receptor 2 |
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| Name: | Discoidin domain-containing receptor 2 |
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| Synonyms: | DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10 |
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| Type: | Protein |
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| Mol. Mass.: | 96717.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16832 |
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| Residue: | 855 |
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| Sequence: | MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
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| BDBM50156123 |
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| n/a |
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| Name | BDBM50156123 |
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| Synonyms: | CHEMBL3780219 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26F3N7O2 |
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| Mol. Mass. | 549.5469 |
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| SMILES | CNc1nc(Nc2ccc(C)c(N)c2)ncc1C(=O)Nc1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C |
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| Structure | 
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