Reaction Details |
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Target | Steroid 21-hydroxylase |
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Ligand | BDBM50391846 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1563733 (CHEMBL3784034) |
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IC50 | >7500±n/a nM |
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Citation | Huang, A; Jayaraman, L; Fura, A; Vite, GD; Trainor, GL; Gottardis, MM; Spires, TE; Spires, VM; Rizzo, CA; Obermeier, MT; Elzinga, PA; Todderud, G; Fan, Y; Newitt, JA; Beyer, SM; Zhu, Y; Warrack, BM; Goodenough, AK; Tebben, AJ; Doweyko, AM; Gold, DL; Balog, A Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett7:40-5 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Steroid 21-hydroxylase |
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Name: | Steroid 21-hydroxylase |
Synonyms: | CP21A_HUMAN | CYP21 | CYP21A2 | CYP21B | Cytochrome P450 21 | Cytochrome P450 21A2 |
Type: | PROTEIN |
Mol. Mass.: | 55896.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1498865 |
Residue: | 494 |
Sequence: | MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHK
KLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDK
IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ
LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTL
SWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRL
QPRGMGAHSPGQNQ
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BDBM50391846 |
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n/a |
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Name | BDBM50391846 |
Synonyms: | CHEMBL2147041 | US9133160, 31 |
Type | Small organic molecule |
Emp. Form. | C15H12F3N3 |
Mol. Mass. | 291.2711 |
SMILES | Cc1ccncc1-c1cccc2n(CC(F)(F)F)cnc12 |
Structure |
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