| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 3 [N508S] |
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| Ligand | BDBM50158094 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1564307 |
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| IC50 | 19000±n/a nM |
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| Citation |  Ferreira de Freitas, R; Eram, MS; Szewczyk, MM; Steuber, H; Smil, D; Wu, H; Li, F; Senisterra, G; Dong, A; Brown, PJ; Hitchcock, M; Moosmayer, D; Stegmann, CM; Egner, U; Arrowsmith, C; Barsyte-Lovejoy, D; Vedadi, M; Schapira, M Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J Med Chem59:1176-83 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 3 [N508S] |
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| Name: | Protein arginine N-methyltransferase 3 [N508S] |
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| Synonyms: | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3) |
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| Type: | Protein |
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| Mol. Mass.: | 59859.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60678[N508S] |
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| Residue: | 531 |
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| Sequence: | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
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| BDBM50158094 |
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| n/a |
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| Name | BDBM50158094 |
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| Synonyms: | CHEMBL3780926 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H22N2 |
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| Mol. Mass. | 218.3379 |
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| SMILES | NCCN1CCC(Cc2ccccc2)CC1 |
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| Structure | 
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